Timberwolves vs. Trail Blazers Predictions, Odds & Stats – Oct. 22

Golden State Warriors v Portland Trail Blazers

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The Minnesota Timberwolves square off against the Portland Trail Blazers as 4.5-point favorites in the first game of the 2025-26 NBA season for both teams on Wednesday, October 22, 2025 at 10 p.m. ET on KUNP and FDSN.

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Listen to the game on Rip City Radio 620 Portland

Timberwolves vs. Trail Blazers Predictions for Wednesday

Our computer projections model for this contest expects a final score of Timberwolves 115, Trail Blazers 109.

  • Moneyline Pick: Timberwolves (-178)
  • Total Pick: Over 221.5 (computer predicts 223.5 points)
  • Pick ATS: Timberwolves (-4.5)

Recent Timberwolves vs. Trail Blazers Matchups

Timberwolves vs Trail Blazers (Recent Matchups)
Date Favorite Spread Total Favorite Moneyline Underdog Moneyline Result
2/8/2025 Timberwolves -3.5 212.5 -163 +137 114-98 MIN
11/13/2024 Timberwolves -10 220 -510 +383 106-98 POR
11/12/2024 Timberwolves -9.5 221.5 -424 +326 122-108 POR
11/8/2024 Timberwolves -12 219.5 -735 +513 127-102 MIN

Timberwolves 2024-25 Betting Trends

  • Minnesota covered the spread 39 times in 82 games last season.
  • As 4.5-point favorites or more, the Timberwolves went 19-22 against the spread last season.
  • Minnesota had 44 of its 82 games go over the point total last year.
  • The Timberwolves put together a 40-23 record in games they were listed as the moneyline favorite last season (winning 63.5% of those games).
  • Minnesota had a record of 29-14 when it played as a moneyline favorite with odds of -178 or shorter last year (67.4%).

Trail Blazers 2024-25 Betting Trends

  • Portland covered 46 times in 82 games with a spread last year.
  • The Trail Blazers went 29-24 as underdogs of 4.5 points or more last season.
  • A total of 40 of Portland's games last year hit the over.
  • The Trail Blazers won 26, or 37.7%, of the 69 games they played as underdogs last season.
  • Portland had a record of 18-36, a 33.3% win rate, when it was set as the underdog by +148 or more by bookmakers last season.

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Timberwolves vs. Trail Blazers Injury Report

Timberwolves

Timberwolves:

Leonard Miller: Out (Finger)

Trail Blazers

Trail Blazers:

Scoot Henderson: Out (Hamstring),

Damian Lillard: Out For Season (Achilles)

Timberwolves vs. Trail Blazers Game Time and TV Channel

  • Game day: Wednesday, October 22, 2025
  • Game time: 10 p.m. ET
  • TV channel: KUNP and FDSN
  • Location: Portland, Oregon
  • Arena: Moda Center
  • Live stream: Watch this game on Fubo (Regional restrictions may apply)

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